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Evaluation of Malaria Rapid Diagnostic Test Based on Detection of PfHRP2 and pLDH in a Meso Endemic Malaria in Indonesia

Kurniawan, A and Tuda, Josef S. B. and Wibowo, H and Winita, R (2015) Evaluation of Malaria Rapid Diagnostic Test Based on Detection of PfHRP2 and pLDH in a Meso Endemic Malaria in Indonesia. In: 51st Annual Scientific Conference of The Malaysian Society of Parasitology & Tropical Medicine, 3-4 March 2015, Kuala Lumpur.

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      Abstract

      Accurate diagnosis is important for successful malaria control program and case management where microscopic examination is not available of feasible. This study aimed to evaluate Pan/Pf malaria RDT based on detection of Pf HRP-II and pLDH and compared with microscopic result. Blood samples were collected during 6-months period in 2014 from patients suspected for clinical malaria in the same district in North Sulawesi, a meso endemic area for malaria. Thick and thin blood smears were made and examined by two well trained microscopist and the rapid test was performed following the procedure in the kit manual using finger prick blood samples. Discordant results from two readers were corrected with the many positive samples and cases with malaria symptoms obtained in July-Augusts and very few samples positive for malaria between October-December. Total prevalence of malaria among the patients with clinical symptoms was 39% (n=208) and 5.5% on the survey among the primary school children (n=103). The Pf HRP2-pLDH RDT based malaria RDT was very sensitive to detect Plasmodium infection among samples with clinical symptoms however it was less sensitive among the survey population. The specificity was lower than its sensitivity. The parasite count was generally low among the population surveved while those with clinical symptoms were high. Further analysis will be discussed.

      Item Type: Conference or Workshop Item (Paper)
      Subjects: R Medicine > R Medicine (General)
      Divisions: Fakultas Kedokteran > Fakultas Kedokteran Umum
      Depositing User: Mr. Benhard W. Tampangela, ST
      Date Deposited: 03 Aug 2017 11:36
      Last Modified: 11 Aug 2017 12:20
      URI: http://repo.unsrat.ac.id/id/eprint/1646

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