HIPERURISEMIA DAN RESPONS IMUN

Manampiring, Aaltje E. (2011) HIPERURISEMIA DAN RESPONS IMUN. JURNAL BIOMEDIK, 3 (2). pp. 103-110. ISSN 2085-9481

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Abstract

Hyperuricemia, a highly prevalent condition in adult population, is associated with hemodynamic and metabolic disturbances. Albeit, pathophysiological aspects of hyperuricemia are still not clearly understood. Uric acid plays an essential role in immunity by induction of some cytokines and chemokines, such as TNFα, I1-1β, IL-6, CXCL8 (IL-8), and CXCL1 (growth-related oncogene α). Deposits of monosodium urate crystals in joint cavities and periarticular tissues are related to an autoinflammatory disturbance, namely gout ======================================= Hiperurisemia merupakan suatu keadaan yang umum dijumpai pada populasi dewasa dan berhubungan dengan kelainan metabolik dan hemodinamik. Aspek patofisiologik dari hiperurisemia belum sepenuhnya dipahami dengan jelas. Asam urat berperan penting dalam imunitas dengan menginduksi berbagai sitokin dan kemokin, antara lain TNFα, I1-1β, IL-6, CXCL8 (IL-8), dan CXCL1 (growth-related oncogene α). Deposit Kristal monosodium urat di dalam rongga sendi dan jaringan periartikuler berkaitan dengan gangguan autoinflamasi yang dikenal sebagai gout.

Item Type:	Article
Uncontrolled Keywords:	hyperuricemia, monosodium urate crystal, immune response hiperurisemia, Kristal monosodium urat, respons imun
Subjects:	R Medicine > R Medicine (General)
Divisions:	Fakultas Kedokteran > Kedokteran Gigi
Depositing User:	Steven Ch. Kaunang
Date Deposited:	20 Jun 2012 05:02
Last Modified:	20 Jun 2012 05:02
URI:	http://repo.unsrat.ac.id/id/eprint/237

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