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Brain Protection Effect of Lidocaine Measured By Interleukin-6 and Phospholipase A2 Concentration in Epidural Haematoma with Moderate Head Injury Patient

Lalenoh, Diana Christine and Bisri, Tatang and Yusuf, Irawan Brain Protection Effect of Lidocaine Measured By Interleukin-6 and Phospholipase A2 Concentration in Epidural Haematoma with Moderate Head Injury Patient. Journal of Anesthesia & Clinical Research. ISSN 2155-6148

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        Abstract

        The aim of this study is to find out the neuroprotective mechanism of lidocaine in epidural haematoma (EDH) in moderate brain injury. The effects are measured by the level of interleukin-6 (IL-6) and phospholipase A2. (PLA2). This siudy is done in forty epidural haematoma patients with moderate brain injury. The objects are divided into two groups, group A with NaCI 0.9% infusion only (control) and group B with NaCI 0.9% infusion combined with lidocaine 1 mg/kg/hr. The blood samples were taken right before induction and two hours after infusion. The result shows that the level of IL-6 and PLA2 is significantly low in group B (p<0.005) with Mann Whitney and Dependent t test. The decreasing level of IL-6 and PLA2 is related with the dose of lidocaine. The inhibition mechanism of IL-6 and PLA2 secretion by lidocaine is considered as a responsible factor in inflammation and brain cells damage. . Summary • Infusion of lidocaine 1 mg/kg/hr will decrease the level of IL-6 in moderate brain injury • Infusion of lidocaine 1 mg/kg/hr will decrease the level of PLA2 in moderate brain injury

        Item Type: Article
        Subjects: R Medicine > R Medicine (General)
        Divisions: Fakultas Kedokteran > Fakultas Kedokteran Umum
        Depositing User: Mr. Benhard W. Tampangela, ST
        Date Deposited: 18 May 2015 11:49
        Last Modified: 23 Sep 2015 14:24
        URI: http://repo.unsrat.ac.id/id/eprint/810

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